Enzündliche Hauterkrankungen I (engl.)

Mechanisms regulating skin immunity and inflammation
Immune responses in the skin are important for host defense against pathogenic microorganisms. However, dysregulated immune reactions can cause chronic inflammatory skin diseases. The skin forms an active barrier that provides the first line of immunological defense against infection. The maintenance of immune homeostasis in the skin relies on a finely tuned equilibrium of well-regulated interactions between different cellular and microbial components. Dysregulation of this equilibrium contributes to the pathogenesis of inflammatory skin diseases such as psoriasis. In barrier tissues such as the intestine and the skin, recent studies have highlighted the crucial role of the communication between host epithelial, stromal and immune cells and the microbiota in the regulation of immune responses.

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Entzündliche HauterkrankungenII (engl.)

Skin and the immune ystem
The skin immune system comprises a complex network of cells, functioning in both immunity against invading pathogens but also tolerogenic mechanisms to ensure maintenance of immune homeostasis. The nature of antigens present and interplay between the cutaneous innate and adaptive immune systems determine the type of immune response generated. Dendritic cells are the key players in bridging innate and adaptive immune response [1]. As the primary immunological barrier to the external environment, the skin is rich in immune cells, forming a complex network called the “skin  immune  system” comprising  both  innate  and  adaptive  immune cells [2]. The uppermost layer of the epidermis, the corneal layer, is comprised of dead keratinocytes that provide a physical barrier to the skin. Keratinocytes produce antimicrobial peptides (AMPs)

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Akne (engl.

Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production, altered keratinisation, inflammation, and bacterial colonisation of hair follicles on the face, neck, chest, and back by Propionibacterium acnes [1].
Causes of acne

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