Skin and the immune ystem
The skin immune system comprises a complex network of cells, functioning in both immunity against invading pathogens but also tolerogenic mechanisms to ensure maintenance of immune homeostasis. The nature of antigens present and interplay between the cutaneous innate and adaptive immune systems determine the type of immune response generated. Dendritic cells are the key players in bridging innate and adaptive immune response . As the primary immunological barrier to the external environment, the skin is rich in immune cells, forming a complex network called the “skin immune system” comprising both innate and adaptive immune cells . The uppermost layer of the epidermis, the corneal layer, is comprised of dead keratinocytes that provide a physical barrier to the skin. Keratinocytes produce antimicrobial peptides (AMPs)
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