Mechanisms regulating skin immunity and inflammation
Immune responses in the skin are important for host defense against pathogenic microorganisms. However, dysregulated immune reactions can cause chronic inflammatory skin diseases. The skin forms an active barrier that provides the first line of immunological defense against infection. The maintenance of immune homeostasis in the skin relies on a finely tuned equilibrium of well-regulated interactions between different cellular and microbial components. Dysregulation of this equilibrium contributes to the pathogenesis of inflammatory skin diseases such as psoriasis. In barrier tissues such as the intestine and the skin, recent studies have highlighted the crucial role of the communication between host epithelial, stromal and immune cells and the microbiota in the regulation of immune responses.
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